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Gene Expression Defines Natural Changes in Mammalian Lifespan

ABSTRACT: Gene Expression Defines Natural Changes in Mammalian Lifespan

PROVIDER: PRJNA184055 | ENA |

REPOSITORIES: ENA

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Gene Expression Defines Natural Changes in Mammalian Lifespan

Project description:Mammals differ more than hundred fold in maximum lifespan, which can be altered in either direction during evolution, but the molecular basis for natural changes in longevity is not understood. Divergent evolution of mammals also led to extensive changes in gene expression within and between lineages. To understand the relationship between lifespan and variation in gene expression, we carried out RNA-seq-based gene expression analyses of liver, kidney and brain of 33 diverse species of mammals. Our analysis uncovered parallel evolution of gene expression and lifespan, as well as the associated life history traits, and identified the processes and pathways involved. These findings provide direct insights into how Nature reversibly adjusts lifespan and other traits during adaptive radiation of lineages. RNA-seq gene expression profiling in normal liver, kidney and brain of 33 mammalian species.

2015-02-17 | E-GEOD-43013 | biostudies-arrayexpress

Gene Expression Defines Natural Changes in Mammalian Lifespan

2015-02-17 | GSE43013 | GEO

Gene expression defines natural changes in mammalian lifespan.

Project description: Not available

| S-EPMC4406664 | biostudies-literature

Evolution of Natural Lifespan Variation and Molecular Strategies of Extended Lifespan

Project description:Here, we analyzed 76 ecologically diverse wild yeast isolates and discovered a wide diversity of replicative lifespan. Phylogenetic analyses pointed to genes and environmental factors that strongly interact to modulate the observed aging patterns. We then identified genetic networks causally associated with natural variation in replicative lifespan across wild yeast isolates, as well as genes, metabolites and pathways, many of which have never been associated with yeast lifespan in laboratory settings. In addition, a combined analysis of lifespan-associated metabolic and transcriptomic changes revealed unique adaptations to interconnected amino acid biosynthesis, glutamate metabolism and mitochondrial function in long-lived strains. Overall, our multi-omic and lifespan analyses across diverse isolates of the same species shows how gene-environment interactions shape cellular processes involved in phenotypic variation such as lifespan.

2021-11-07 | GSE188294 | GEO

Evolution of Natural Lifespan Variation and Molecular Strategies of Extended Lifespan

Project description:Evolution of Natural Lifespan Variation and Molecular Strategies of Extended Lifespan

| PRJNA778214 | ENA

Epithelial zonation along the mammalian small intestine defines five discrete metabolic domains [Human_scRNA-seq]

Project description:Longitudinal zonation of epithelial cells across the mammalian small intestine defines five domains of nutrient absorption.

2023-11-28 | GSE201857 | GEO

Epithelial zonation along the mammalian small intestine defines five discrete metabolic domains [Mouse_scRNA-seq]

Project description:Longitudinal zonation of epithelial cells across the mammalian small intestine defines five domains of nutrient absorption.

2023-11-28 | GSE201855 | GEO

Epithelial zonation along the mammalian small intestine defines five discrete metabolic domains [Human_scRNA-seq II]

Project description:Longitudinal zonation of epithelial cells across the mammalian small intestine defines five domains of nutrient absorption.

2023-12-21 | GSE251695 | GEO

Epithelial zonation along the mammalian small intestine defines five discrete metabolic domains [Mouse_scRNA-seq II]

Project description:Longitudinal zonation of epithelial cells across the mammalian small intestine defines five domains of nutrient absorption.

2023-12-21 | GSE251694 | GEO

Epithelial zonation along the mammalian small intestine defines five discrete metabolic domains [Mouse_bulkRNA-seq]

Project description:Longitudinal zonation of epithelial cells across the mammalian small intestine defines five domains of nutrient absorption. We then performed gene expression profiling analysis using data obtained from RNA-seq of 4 different cells at two time points.

2023-11-28 | GSE201858 | GEO

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