Dataset Information


Mus musculus

ABSTRACT: Oncogenic Nras has a bimodal effect on hematopoietic stem cells promoting proliferation and self-renewal

ORGANISM(S): Mus musculus  



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Oncogenic Nras has bimodal effects on stem cells that sustainably increase competitiveness.

Li Qing Q   Bohin Natacha N   Wen Tiffany T   Ng Victor V   Magee Jeffrey J   Chen Shann-Ching SC   Shannon Kevin K   Morrison Sean J SJ  

Nature 20131127 7478

'Pre-leukaemic' mutations are thought to promote clonal expansion of haematopoietic stem cells (HSCs) by increasing self-renewal and competitiveness; however, mutations that increase HSC proliferation tend to reduce competitiveness and self-renewal potential, raising the question of how a mutant HSC can sustainably outcompete wild-type HSCs. Activating mutations in NRAS are prevalent in human myeloproliferative neoplasms and leukaemia. Here we show that a single allele of oncogenic Nras(G12D) in  ...[more]

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