Dataset Information


Homo sapiens

ABSTRACT: Location of indigenous human HSCs reveals functional properties of HSCs that are dictated by anatomic and cellular architecture of bone marrow I

ORGANISM(S): Homo sapiens  



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Regional localization within the bone marrow influences the functional capacity of human HSCs.

Guezguez Borhane B   Campbell Clinton J V CJ   Boyd Allison L AL   Karanu Francis F   Casado Fanny L FL   Di Cresce Christine C   Collins Tony J TJ   Shapovalova Zoya Z   Xenocostas Anargyros A   Bhatia Mickie M  

Cell stem cell 20130801 2

Numerous studies have shown that the bone marrow (BM) niche plays a key role in mouse hematopoietic stem cell (HSC) function and involves contributions from a broad array of cell types. However, the composition and role of the human BM HSC niche have not been investigated. Here, using human bone biopsy specimens, we provide evidence of HSC propensity to localize to endosteal regions of the trabecular bone area (TBA). Through functional xenograft transplantation, we found that human HSCs localizi  ...[more]

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