Dataset Information


Mus musculus

ABSTRACT: Analysis of TBR1 downnstream target genes in embryonic forebrains

ORGANISM(S): Mus musculus  



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Tbr1 haploinsufficiency impairs amygdalar axonal projections and results in cognitive abnormality.

Huang Tzyy-Nan TN   Chuang Hsiu-Chun HC   Chou Wen-Hsi WH   Chen Chiung-Ya CY   Wang Hsiao-Fang HF   Chou Shen-Ju SJ   Hsueh Yi-Ping YP  

Nature neuroscience 20140119 2

The neuron-specific transcription factor T-box brain 1 (TBR1) regulates brain development. Disruptive mutations in the TBR1 gene have been repeatedly identified in patients with autism spectrum disorders (ASDs). Here, we show that Tbr1 haploinsufficiency results in defective axonal projections of amygdalar neurons and the impairment of social interaction, ultrasonic vocalization, associative memory and cognitive flexibility in mice. Loss of a copy of the Tbr1 gene altered the expression of Ntng1  ...[more]

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