Dataset Information


Homo sapiens

ABSTRACT: miRNA regulation in diabetes associated impaired wound healing

ORGANISM(S): Homo sapiens  



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Impairment of Wound Healing in Patients With Type 2 Diabetes Mellitus Influences Circulating MicroRNA Patterns via Inflammatory Cytokines.

Dangwal Seema S   Stratmann Bernd B   Bang Claudia C   Lorenzen Johan M JM   Kumarswamy Regalla R   Fiedler Jan J   Falk Christine S CS   Scholz Claus J CJ   Thum Thomas T   Tschoepe Diethelm D  

Arteriosclerosis, thrombosis, and vascular biology 20150326 6

OBJECTIVE: MicroRNAs (miRNA/miR) are stably present in body fluids and are increasingly explored as disease biomarkers. Here, we investigated influence of impaired wound healing on the plasma miRNA signature and their functional importance in patients with type 2 diabetes mellitus. APPROACH AND RESULTS: miRNA array profiling identified 41 miRNAs significantly deregulated in diabetic controls when compared with patients with diabetes mellitus-associated peripheral arterial disease and chronic wou  ...[more]

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