Genomics

Dataset Information

118

Danio rerio


ABSTRACT: Transcriptome analysis of heart regeneration in adult zebrafish

ORGANISM(S): Danio rerio  

PROVIDER: PRJNA217180 | ENA |

REPOSITORIES: ENA

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Publications


While the adult human heart has very limited regenerative potential, the adult zebrafish heart can fully regenerate after 20% ventricular resection. Although previous reports suggest that developmental signaling pathways such as FGF and PDGF are reused in adult heart regeneration, the underlying intracellular mechanisms remain largely unknown. Here we show that H2O2 acts as a novel epicardial and myocardial signal to prime the heart for regeneration in adult zebrafish. Live imaging of intact hea  ...[more]

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