Dataset Information


Mus musculus

ABSTRACT: 4T1 cells with Control vs SNAIL vs SNAIL/FBXO11

ORGANISM(S): Mus musculus  



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PKD1 phosphorylation-dependent degradation of SNAIL by SCF-FBXO11 regulates epithelial-mesenchymal transition and metastasis.

Zheng Hanqiu H   Shen Minhong M   Zha Yin-Lian YL   Li Wenyang W   Wei Yong Y   Blanco Mario Andres MA   Ren Guangwen G   Zhou Tianhua T   Storz Peter P   Wang Hui-Yun HY   Kang Yibin Y  

Cancer cell 20140901 3

Metastatic dissemination is often initiated by the reactivation of an embryonic development program referred to as epithelial-mesenchymal transition (EMT). The transcription factor SNAIL promotes EMT and elicits associated pathological characteristics such as invasion, metastasis, and stemness. To better understand the posttranslational regulation of SNAIL, we performed a luciferase-based, genome-wide E3 ligase siRNA library screen and identified SCF-FBXO11 as an important E3 that targets SNAIL  ...[more]

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