Dataset Information


Homo sapiens

ABSTRACT: Neuroblastoma: MYCN normal vs. MYCN amplified

ORGANISM(S): Homo sapiens  



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Aryl hydrocarbon receptor downregulates MYCN expression and promotes cell differentiation of neuroblastoma.

Wu Pei-Yi PY   Liao Yung-Feng YF   Juan Hsueh-Fen HF   Huang Hsuan-Cheng HC   Wang Bo-Jeng BJ   Lu Yen-Lin YL   Yu I-Shing IS   Shih Yu-Yin YY   Jeng Yung-Ming YM   Hsu Wen-Ming WM   Lee Hsinyu H  

PloS one 20140221 2

Neuroblastoma (NB) is the most common malignant disease of infancy. MYCN amplification is a prognostic factor for NB and is a sign of highly malignant disease and poor patient prognosis. In this study, we aimed to investigate novel MYCN-related genes and assess how they affect NB cell behavior. The different gene expression found in 10 MYCN amplification NB tumors and 10 tumors with normal MYCN copy number were analyzed using tissue oligonucleotide microarrays. Ingenuity Pathway Analysis was sub  ...[more]

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