Project description:Human Polynucleotide Phosphorylase (hPNPaseold-35) is an evolutionarily conserved 3’→5’ exoribonuclease implicated in the regulation of numerous physiological processes like maintenance of mitochondrial homeostasis, mtRNA import and aging-associated inflammation. From an RNase perspective, little is known about the RNA or miRNA species it targets for degradation or whose expression it regulates; except for c-myc and miR-221. To further elucidate the functional implications of hPNPaseold-35 in cellular physiology, we knocked-down and overexpressed hPNPaseold-35 in melanoma cells and performed gene expression analyses to identify differentially expressed transcripts. Biological triplicates were run on microarrays.

2013-07-30 | E-GEOD-46884 | biostudies-arrayexpress

Analysis of global changes in gene expression induced by human polynucleotide phosphorylase (hPNPaseold-35)

Project description:Human Polynucleotide Phosphorylase (hPNPaseold-35) is an evolutionarily conserved 3’?5’ exoribonuclease implicated in the regulation of numerous physiological processes like maintenance of mitochondrial homeostasis, mtRNA import and aging-associated inflammation. From an RNase perspective, little is known about the RNA or miRNA species it targets for degradation or whose expression it regulates; except for c-myc and miR-221. To further elucidate the functional implications of hPNPaseold-35 in cellular physiology, we knocked-down and overexpressed hPNPaseold-35 in melanoma and HeLa cells, respectively, and performed gene expression analyses to identify differentially expressed transcripts. Biological triplicates were run on microarrays.

2014-06-01 | E-GEOD-53604 | biostudies-arrayexpress

E-GEOD-46884

Project description:Gene Expression Signature of Human Polynucleotide Phosphorylase (hPNPaseold-35) in Melanoma

2015-06-18 | E-GEOD-46884 | ExpressionAtlas

Arabidopsis thaliana

Project description:Chloroplast polynucleotide phosphorylase null mutant (pnp1-1) and phosphate starvation

| PRJNA119339 | ENA

Global analysis of mRNA decay intermediates in Bacillus subtilis wild-type and polynucleotide phosphorylase-deletion strains

Project description:Global analysis of mRNA decay intermediates in Bacillus subtilis wild-type and polynucleotide phosphorylase-deletion strains

| PRJNA491499 | ENA

Homo sapiens

Project description:PGN induced transcriptional changes in human neonatal neutrophils