Dataset Information


Mus musculus

ABSTRACT: Aorta- and liver-specific ERalpha-binding patterns and gene regulation by estrogen

ORGANISM(S): Mus musculus  



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Research resource: Aorta- and liver-specific ERα-binding patterns and gene regulation by estrogen.

Gordon Francesca K FK   Vallaster Caroline S CS   Westerling Thomas T   Iyer Lakshmanan K LK   Brown Myles M   Schnitzler Gavin R GR  

Molecular endocrinology (Baltimore, Md.) 20140703 8

Estrogen has vascular protective effects in premenopausal women and in women younger than 60 years who are receiving hormone replacement therapy. However, estrogen also increases the risks of breast and uterine cancers and of venous thromboses linked to up-regulation of coagulation factors in the liver. In mouse models, the vasculoprotective effects of estrogen are mediated by the estrogen receptor α (ERα) transcription factor. Here, through next-generation sequencing approaches, we show that al  ...[more]

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