Genomics

Dataset Information

235

Mus musculus


ABSTRACT: Aorta- and liver-specific ERalpha-binding patterns and gene regulation by estrogen

ORGANISM(S): Mus musculus  

PROVIDER: PRJNA248130 | ENA |

REPOSITORIES: ENA

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Publications

Research resource: Aorta- and liver-specific ERα-binding patterns and gene regulation by estrogen.

Gordon Francesca K FK   Vallaster Caroline S CS   Westerling Thomas T   Iyer Lakshmanan K LK   Brown Myles M   Schnitzler Gavin R GR  

Molecular Endocrinology 20140703 8


Estrogen has vascular protective effects in premenopausal women and in women younger than 60 years who are receiving hormone replacement therapy. However, estrogen also increases the risks of breast and uterine cancers and of venous thromboses linked to up-regulation of coagulation factors in the liver. In mouse models, the vasculoprotective effects of estrogen are mediated by the estrogen receptor α (ERα) transcription factor. Here, through next-generation sequencing approaches, we show that al  ...[more]

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