Dataset Information


Mus musculus

ABSTRACT: Ptf1a promotes an inhibitory peptidergic identity in cortical pyramidal cells in vivo

ORGANISM(S): Mus musculus  



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Misexpression of ptf1a in cortical pyramidal cells in vivo promotes an inhibitory peptidergic identity.

Russ Jeffrey B JB   Borromeo Mark D MD   Kollipara Rahul K RK   Bommareddy Praveen K PK   Johnson Jane E JE   Kaltschmidt Julia A JA  

The Journal of neuroscience : the official journal of the Society for Neuroscience 20150401 15

The intracellular transcriptional milieu wields considerable influence over the induction of neuronal identity. The transcription factor Ptf1a has been proposed to act as an identity "switch" between developmentally related precursors in the spinal cord (Glasgow et al., 2005; Huang et al., 2008), retina (Fujitani et al., 2006; Dullin et al., 2007; Nakhai et al., 2007; Lelièvre et al., 2011), and cerebellum (Hoshino et al., 2005; Pascual et al., 2007; Yamada et al., 2014), where it promotes an in  ...[more]

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