Dataset Information


Bos taurus

ABSTRACT: Expression data from bovine nucleus pulposus interverteral disc cells

ORGANISM(S): Bos taurus  



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Deficiency in the α1 subunit of Na+/K+-ATPase enhances the anti-proliferative effect of high osmolality in nucleus pulposus intervertebral disc cells.

Mavrogonatou Eleni E   Papadimitriou Konstantinos K   Urban Jill P JP   Papadopoulos Vassilios V   Kletsas Dimitris D  

Journal of cellular physiology 20151201 12

Intervertebral disc cells are constantly exposed to a hyperosmotic environment. Among cellular responses towards this stress is the inhibition of proliferation through the activation of p38 MAPK and p53. In an effort to further elucidate the biochemical pathways triggered by hyperosmotic stress, we assessed the high osmolality-induced transcriptional changes of bovine nucleus pulposus cells using whole-genome arrays. A 5- and a 24-h hyperosmotic treatment led to the differential expression of >1  ...[more]

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