Dataset Information


Mus musculus

ABSTRACT: Circadian Enhancers Coordinate Multiple Phases of Rhythmic Gene Transcription In Vivo

ORGANISM(S): Mus musculus  



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Circadian enhancers coordinate multiple phases of rhythmic gene transcription in vivo.

Fang Bin B   Everett Logan J LJ   Jager Jennifer J   Briggs Erika E   Armour Sean M SM   Feng Dan D   Roy Ankur A   Gerhart-Hines Zachary Z   Sun Zheng Z   Lazar Mitchell A MA  

Cell 20141101 5

Mammalian transcriptomes display complex circadian rhythms with multiple phases of gene expression that cannot be accounted for by current models of the molecular clock. We have determined the underlying mechanisms by measuring nascent RNA transcription around the clock in mouse liver. Unbiased examination of enhancer RNAs (eRNAs) that cluster in specific circadian phases identified functional enhancers driven by distinct transcription factors (TFs). We further identify on a global scale the com  ...[more]

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