Genomics

Dataset Information

0

Mus musculus


ABSTRACT: The effect of Vdr gene ablation in the mouse placenta

ORGANISM(S): Mus musculus  

PROVIDER: PRJNA261529 | ENA |

REPOSITORIES: ENA

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Publications

The effect of Vdr gene ablation on global gene expression in the mouse placenta.

Buckberry Sam S   Spronk Fleur F   Wilson Rebecca L RL   Laurence Jessica A JA   Bianco-Miotto Tina T   Leemaqz Shalem S   O'Leary Sean S   Anderson Paul H PH   Roberts Claire T CT  

Genomics data 20150818


The effects of vitamin D are mediated through the vitamin D receptor (VDR), a predominantly nuclear receptor, expressed in numerous tissues including the placenta. VDR and the retinoid X receptor (RXR) form a dimer complex which binds to genomic vitamin D responsive elements located primarily in promoter regions and recruit cell-specific transcription factor complexes which regulate the expression of numerous genes. To investigate the role of VDR on regulating placental gene expression, mice het  ...[more]

Publication: 1/2

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