Genomics

Dataset Information

176

Homo sapiens


ABSTRACT: The histone H3.3K27M mutation in pediatric glioma reprograms H3K27 methylation and gene expression

ORGANISM(S): Homo sapiens  

PROVIDER: PRJNA261535 | ENA |

REPOSITORIES: ENA

altmetric image

Publications

The histone H3.3K27M mutation in pediatric glioma reprograms H3K27 methylation and gene expression.

Chan Kui-Ming KM   Fang Dong D   Gan Haiyun H   Hashizume Rintaro R   Yu Chuanhe C   Schroeder Mark M   Gupta Nalin N   Mueller Sabine S   James C David CD   Jenkins Robert R   Sarkaria Jann J   Zhang Zhiguo Z  

Genes & Development 20130419 9


Recent studies have identified a Lys 27-to-methionine (K27M) mutation at one allele of H3F3A, one of the two genes encoding histone H3 variant H3.3, in 60% of high-grade pediatric glioma cases. The median survival of this group of patients after diagnosis is ∼1 yr. Here we show that the levels of H3K27 di- and trimethylation (H3K27me2 and H3K27me3) are reduced globally in H3.3K27M patient samples due to the expression of the H3.3K27M mutant allele. Remarkably, we also observed that H3K27me3 and  ...[more]

Similar Datasets

2014-09-20 | E-GEOD-61586 | ArrayExpress
| GSE61586 | GEO
2019-04-09 | PXD013390 | Pride
2018-07-02 | GSE94834 | GEO
| GSE95277 | GEO
2014-09-02 | E-GEOD-59891 | ArrayExpress
| GSE59891 | GEO
2018-04-05 | PXD005381 | Pride
| GSE100826 | GEO
2014-03-15 | E-GEOD-55920 | ArrayExpress