Genomics

Dataset Information

235

Homo sapiens


ABSTRACT: YAP drives proliferation and tumorigenesis by recruiting Mediator to super- enhancer elements (CClp1)

ORGANISM(S): Homo sapiens  

PROVIDER: PRJNA263636 | ENA |

REPOSITORIES: ENA

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Publications


The Hippo/YAP signaling pathway is a crucial regulator of tissue growth, stem cell activity, and tumorigenesis. However, the mechanism by which YAP controls transcription remains to be fully elucidated. Here, we utilize global chromatin occupancy analyses to demonstrate that robust YAP binding is restricted to a relatively small number of distal regulatory elements in the genome. YAP occupancy defines a subset of enhancers and superenhancers with the highest transcriptional outputs. YAP modulate  ...[more]

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