Genomics

Dataset Information

412

Homo sapiens


ABSTRACT: Autophagy mediates degradation of nuclear lamina

ORGANISM(S): Homo sapiens  

PROVIDER: PRJNA267739 | ENA |

REPOSITORIES: ENA

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Publications


Macroautophagy (hereafter referred to as autophagy) is a catabolic membrane trafficking process that degrades a variety of cellular constituents and is associated with human diseases. Although extensive studies have focused on autophagic turnover of cytoplasmic materials, little is known about the role of autophagy in degrading nuclear components. Here we report that the autophagy machinery mediates degradation of nuclear lamina components in mammals. The autophagy protein LC3/Atg8, which is inv  ...[more]

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