Genomics

Dataset Information

235

Homo sapiens


ABSTRACT: A study of alterations in DNA epigenetic modifications (5mC and 5hmC) and gene expression influenced by simulated microgravity in human lymphoblastoid cells [meDIP-seq]

ORGANISM(S): Homo sapiens  

PROVIDER: PRJNA274134 | ENA |

REPOSITORIES: ENA

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Publications

A Study of Alterations in DNA Epigenetic Modifications (5mC and 5hmC) and Gene Expression Influenced by Simulated Microgravity in Human Lymphoblastoid Cells.

Chowdhury Basudev B   Seetharam Arun A   Wang Zhiping Z   Liu Yunlong Y   Lossie Amy C AC   Thimmapuram Jyothi J   Irudayaraj Joseph J  

PloS one 20160128 1


Cells alter their gene expression in response to exposure to various environmental changes. Epigenetic mechanisms such as DNA methylation are believed to regulate the alterations in gene expression patterns. In vitro and in vivo studies have documented changes in cellular proliferation, cytoskeletal remodeling, signal transduction, bone mineralization and immune deficiency under the influence of microgravity conditions experienced in space. However microgravity induced changes in the epigenome h  ...[more]

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