Genomics

Dataset Information

118

Systematic Identification of Factors Crucial for Provirus Silencing in Embryonic Stem Cells


ABSTRACT: Systematic Identification of Factors Crucial for Provirus Silencing in Embryonic Stem Cells

PROVIDER: PRJNA289720 | ENA |

REPOSITORIES: ENA

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Embryonic stem cells (ESCs) repress the expression of exogenous proviruses and endogenous retroviruses (ERVs). Here, we systematically dissected the cellular factors involved in provirus repression in embryonic carcinomas (ECs) and ESCs by a genome-wide siRNA screen. Histone chaperones (Chaf1a/b), sumoylation factors (Sumo2/Ube2i/Sae1/Uba2/Senp6), and chromatin modifiers (Trim28/Eset/Atf7ip) are key determinants that establish provirus silencing. RNA-seq analysis uncovered the roles of Chaf1a/b  ...[more]

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