Genomics

Dataset Information

0

Mus musculus


ABSTRACT: The Estrogen Receptor Co-Regulator Protein, Proline Glutamic Acid and Leucine Rich Protein 1 (PELP1) Mediates Estrogen Rapid Signaling and Neuroprotection in the Brain

ORGANISM(S): Mus musculus  

PROVIDER: PRJNA293161 | ENA |

REPOSITORIES: ENA

Dataset's files

Source:
Action DRS
SRR2171000.fastq.gz Fastqsanger.gz
SRR2171001.fastq.gz Fastqsanger.gz
SRR2170998.fastq.gz Fastqsanger.gz
SRR2170999.fastq.gz Fastqsanger.gz
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Publications

Proline-, glutamic acid-, and leucine-rich protein 1 mediates estrogen rapid signaling and neuroprotection in the brain.

Sareddy Gangadhara R GR   Zhang Quanguang Q   Wang Ruimin R   Scott Erin E   Zou Yi Y   O'Connor Jason C JC   Chen Yidong Y   Dong Yan Y   Vadlamudi Ratna K RK   Brann Darrell D  

Proceedings of the National Academy of Sciences of the United States of America 20151116 48


17-β estradiol (E2) has been implicated as neuroprotective in a variety of neurodegenerative disorders. However, the underlying mechanism remains unknown. Here, we provide genetic evidence, using forebrain-specific knockout (FBKO) mice, that proline-, glutamic acid-, and leucine-rich protein 1 (PELP1), an estrogen receptor coregulator protein, is essential for the extranuclear signaling and neuroprotective actions of E2 in the hippocampal CA1 region after global cerebral ischemia (GCI). E2-media  ...[more]

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