Dataset Information


Mus musculus

ABSTRACT: Allelic Series of Huntington's Disease Knock-in Mice Reveals Expression Discorrelates

ORGANISM(S): Mus musculus  



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Allelic series of Huntington's disease knock-in mice reveals expression discorrelates.

Kumar Ashish A   Zhang Jennifer J   Tallaksen-Greene Sara S   Crowley Michael R MR   Crossman David K DK   Morton A Jennifer AJ   Van Groen Thomas T   Kadish Inga I   Albin Roger L RL   Lesort Mathieu M   Detloff Peter J PJ  

Human molecular genetics 20160214 8

Identifying molecular drivers of pathology provides potential therapeutic targets. Differentiating between drivers and coincidental molecular alterations presents a major challenge. Variation unrelated to pathology further complicates transcriptomic, proteomic and metabolomic studies which measure large numbers of individual molecules. To overcome these challenges towards the goal of determining drivers of Huntington's disease (HD), we generated an allelic series of HD knock-in mice with graded  ...[more]

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