Genomics

Dataset Information

316

Homo sapiens


ABSTRACT: HITS-CLIP miRNA targetome EBV

PROVIDER: PRJNA309583 | ENA |

REPOSITORIES: ENA

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Publications

EBV and human microRNAs co-target oncogenic and apoptotic viral and human genes during latency.

Riley Kasandra J KJ   Rabinowitz Gabrielle S GS   Yario Therese A TA   Luna Joseph M JM   Darnell Robert B RB   Steitz Joan A JA  

The EMBO journal 20120330 9


Epstein-Barr virus (EBV) controls gene expression to transform human B cells and maintain viral latency. High-throughput sequencing and crosslinking immunoprecipitation (HITS-CLIP) identified mRNA targets of 44 EBV and 310 human microRNAs (miRNAs) in Jijoye (Latency III) EBV-transformed B cells. While 25% of total cellular miRNAs are viral, only three viral mRNAs, all latent transcripts, are targeted. Thus, miRNAs do not control the latent/lytic switch by targeting EBV lytic genes. Unexpectedly,  ...[more]

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