Dataset Information


Mus musculus

ABSTRACT: Gene expression analysis in mouse podocytes expressing shRNA directed against the long noncoding RNA Tug1

ORGANISM(S): Mus musculus  



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Long noncoding RNA Tug1 regulates mitochondrial bioenergetics in diabetic nephropathy.

Long Jianyin J   Badal Shawn S SS   Ye Zengchun Z   Wang Yin Y   Ayanga Bernard A BA   Galvan Daniel L DL   Green Nathanael H NH   Chang Benny H BH   Overbeek Paul A PA   Danesh Farhad R FR  

The Journal of clinical investigation 20161017 11

The regulatory roles of long noncoding RNAs (lncRNAs) in transcriptional coactivators are still largely unknown. Here, we have shown that the peroxisome proliferator-activated receptor γ (PPARγ) coactivator α (PGC-1α, encoded by Ppargc1a) is functionally regulated by the lncRNA taurine-upregulated gene 1 (Tug1). Further, we have described a role for Tug1 in the regulation of mitochondrial function in podocytes. Using a murine model of diabetic nephropathy (DN), we performed an unbiased RNA-seque  ...[more]

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