Genomics

Dataset Information

235

Danio rerio


ABSTRACT: Cortisol-treated zebrafish embryos develop into pro-inflammatory adults with aberrant immune gene regulation [adults]

ORGANISM(S): Danio rerio  

PROVIDER: PRJNA318414 | ENA |

REPOSITORIES: ENA

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Publications

Cortisol-treated zebrafish embryos develop into pro-inflammatory adults with aberrant immune gene regulation.

Hartig Ellen I EI   Zhu Shusen S   King Benjamin L BL   Coffman James A JA  

Biology open 20160815 8


Chronic early-life stress increases adult susceptibility to numerous health problems linked to chronic inflammation. One way that this may occur is via glucocorticoid-induced developmental programming. To gain insight into such programming we treated zebrafish embryos with cortisol and examined the effects on both larvae and adults. Treated larvae had elevated whole-body cortisol and glucocorticoid signaling, and upregulated genes associated with defense response and immune system processes. In  ...[more]

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