Dataset Information


Schistosoma mansoni

ABSTRACT: Schistosomula exposed to HDAC inhibitor (Trichostatin A) [48hrs]



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Histone deacetylase inhibition modulates histone acetylation at gene promoter regions and affects genome-wide gene transcription in Schistosoma mansoni.

Anderson Letícia L   Gomes Monete Rajão MR   daSilva Lucas Ferreira LF   Pereira Adriana da Silva Andrade ADSA   Mourão Marina M MM   Romier Christophe C   Pierce Raymond R   Verjovski-Almeida Sergio S  

PLoS neglected tropical diseases 20170413 4

<h4>Background</h4>Schistosomiasis is a parasitic disease infecting hundreds of millions of people worldwide. Treatment depends on a single drug, praziquantel, which kills the Schistosoma spp. parasite only at the adult stage. HDAC inhibitors (HDACi) such as Trichostatin A (TSA) induce parasite mortality in vitro (schistosomula and adult worms), however the downstream effects of histone hyperacetylation on the parasite are not known.<h4>Methodology/principal findings</h4>TSA treatment of adult w  ...[more]

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