Genomics

Dataset Information

235

Distinct cell cycle control in naïve and primed mouse pluripotency


ABSTRACT: Distinct cell cycle control in naïve and primed mouse pluripotency

PROVIDER: PRJNA339107 | ENA |

REPOSITORIES: ENA

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Publications

Distinct Cell-Cycle Control in Two Different States of Mouse Pluripotency.

Ter Huurne Menno M   Chappell James J   Dalton Stephen S   Stunnenberg Hendrik G HG  

Cell stem cell 20171001 4


Mouse embryonic stem cells (ESCs) cultured in serum are characterized by hyper-phosphorylated RB protein, lack of G1 control, and rapid progression through the cell cycle. Here, we show that ESCs grown in the presence of two small-molecule inhibitors (2i ESCs) have a longer G1-phase with hypo-phosphorylated RB, implying that they have a functional G1 checkpoint. Deletion of RB, P107, and P130 in 2i ESCs results in a G1-phase similar to that of serum ESCs. Inhibition of the ERK signaling pathway  ...[more]

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