Genomics

Dataset Information

267

Homo sapiens


ABSTRACT: RNA-seq of naive and primed ES cells (NHSM)

ORGANISM(S): Homo sapiens  

PROVIDER: PRJNA339108 | ENA |

REPOSITORIES: ENA

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Publications


Recent studies have aimed to convert cultured human pluripotent cells to a naive state, but it remains unclear to what extent the resulting cells recapitulate in vivo naive pluripotency. Here we propose a set of molecular criteria for evaluating the naive human pluripotent state by comparing it to the human embryo. We show that transcription of transposable elements provides a sensitive measure of the concordance between pluripotent stem cells and early human development. We also show that induc  ...[more]

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