Dataset Information


Mus musculus

ABSTRACT: Induction of alternative proinflammatory cytokines accounts for sustained psoriasiform skin inflammation in IL-17C+IL-6KO mice [RNA-Seq]

ORGANISM(S): Mus musculus  



altmetric image


Induction of Alternative Proinflammatory Cytokines Accounts for Sustained Psoriasiform Skin Inflammation in IL-17C+IL-6KO Mice.

Fritz Yi Y   Klenotic Philip A PA   Swindell William R WR   Yin Zhi Qiang ZQ   Groft Sarah G SG   Zhang Li L   Baliwag Jaymie J   Camhi Maya I MI   Diaconu Doina D   Young Andrew B AB   Foster Alexander M AM   Johnston Andrew A   Gudjonsson Johann E JE   McCormick Thomas S TS   Ward Nicole L NL  

The Journal of investigative dermatology 20161027 3

IL-6 inhibition has been unsuccessful in treating psoriasis, despite high levels of tissue and serum IL-6 in patients. In addition, de novo psoriasis onset has been reported after IL-6 blockade in patients with rheumatoid arthritis. To explore mechanisms underlying these clinical observations, we backcrossed an established psoriasiform mouse model (IL-17C+ mice) with IL-6-deficient mice (IL-17C+KO) and examined the cutaneous phenotype. IL-17C+KO mice initially exhibited decreased skin inflammati  ...[more]

Similar Datasets

| PRJNA340379 | ENA
| PRJNA340413 | ENA
| GSE85967 | GEO
| GSE86139 | GEO
| PRJEB15422 | ENA
| GSE79642 | GEO
2011-03-15 | GSE26912 | GEO
2011-03-15 | E-GEOD-26912 | ArrayExpress
2016-02-19 | E-GEOD-78057 | ArrayExpress
| GSE79704 | GEO