Genomics

Dataset Information

140

Mus musculus


ABSTRACT: Induction of alternative proinflammatory cytokines accounts for sustained psoriasiform skin inflammation in IL-17C+IL-6KO mice [RNA-Seq]

ORGANISM(S): Mus musculus  

PROVIDER: PRJNA339850 | ENA |

REPOSITORIES: ENA

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Publications

Induction of Alternative Proinflammatory Cytokines Accounts for Sustained Psoriasiform Skin Inflammation in IL-17C+IL-6KO Mice.

Fritz Yi Y   Klenotic Philip A PA   Swindell William R WR   Yin Zhi Qiang ZQ   Groft Sarah G SG   Zhang Li L   Baliwag Jaymie J   Camhi Maya I MI   Diaconu Doina D   Young Andrew B AB   Foster Alexander M AM   Johnston Andrew A   Gudjonsson Johann E JE   McCormick Thomas S TS   Ward Nicole L NL  

The Journal of investigative dermatology 20161027 3


IL-6 inhibition has been unsuccessful in treating psoriasis, despite high levels of tissue and serum IL-6 in patients. In addition, de novo psoriasis onset has been reported after IL-6 blockade in patients with rheumatoid arthritis. To explore mechanisms underlying these clinical observations, we backcrossed an established psoriasiform mouse model (IL-17C+ mice) with IL-6-deficient mice (IL-17C+KO) and examined the cutaneous phenotype. IL-17C+KO mice initially exhibited decreased skin inflammati  ...[more]

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