Genomics

Dataset Information

59

Molecular analysis of renal cell carcinoma with unclassfied histology


ABSTRACT: Molecular analysis of renal cell carcinoma with unclassfied histology

PROVIDER: PRJNA339856 | ENA |

REPOSITORIES: ENA

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Publications


Renal cell carcinomas with unclassified histology (uRCC) constitute a significant portion of aggressive non-clear cell renal cell carcinomas that have no standard therapy. The oncogenic drivers in these tumours are unknown. Here we perform a molecular analysis of 62 high-grade primary uRCC, incorporating targeted cancer gene sequencing, RNA sequencing, single-nucleotide polymorphism array, fluorescence in situ hybridization, immunohistochemistry and cell-based assays. We identify recurrent somat  ...[more]

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