Dataset Information


Homo sapiens

ABSTRACT: eIF1 modulates the recognition of sub-optimal translation start sites and steers gene expression control mediated by uORFs

ORGANISM(S): Homo sapiens  



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SRR4293693.fastq.gz Fastqsanger.gz
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eIF1 modulates the recognition of suboptimal translation initiation sites and steers gene expression via uORFs.

Fijalkowska Daria D   Verbruggen Steven S   Ndah Elvis E   Jonckheere Veronique V   Menschaert Gerben G   Van Damme Petra P  

Nucleic acids research 20170701 13

Alternative translation initiation mechanisms such as leaky scanning and reinitiation potentiate the polycistronic nature of human transcripts. By allowing for reprogrammed translation, these mechanisms can mediate biological responses to stimuli. We combined proteomics with ribosome profiling and mRNA sequencing to identify the biological targets of translation control triggered by the eukaryotic translation initiation factor 1 (eIF1), a protein implicated in the stringency of start codon selec  ...[more]

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