Dataset Information


Homo sapiens

ABSTRACT: Single-cell RNA-seq reveals heterogeneity within human pre-cDCs

ORGANISM(S): Homo sapiens  



Dataset's files

Action DRS
SRR4455090.fastq.gz Fastqsanger.gz
SRR4455100.fastq.gz Fastqsanger.gz
SRR4455110.fastq.gz Fastqsanger.gz
SRR4455120.fastq.gz Fastqsanger.gz
SRR4455130.fastq.gz Fastqsanger.gz
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Human dendritic cells (DCs) are derived from distinct circulating precursors that are precommitted to become CD1c+ or CD141+ DCs.

Breton Gaëlle G   Zheng Shiwei S   Valieris Renan R   Tojal da Silva Israel I   Satija Rahul R   Nussenzweig Michel C MC  

The Journal of experimental medicine 20161118 13

In humans, conventional dendritic cells (cDCs) exist as two unique populations characterized by expression of CD1c and CD141. cDCs arise from increasingly restricted but well-defined bone marrow progenitors that include the common DC progenitor that differentiates into the pre-cDC, which is the direct precursor of cDCs. In this study, we show that pre-cDCs in humans are heterogeneous, consisting of two distinct populations of precursors that are precommitted to become either CD1c<sup>+</sup> or  ...[more]

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