Genomics

Dataset Information

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Therapeutic targeting MLL degradation pathways in MLL-rearranged leukemia


ABSTRACT: Therapeutic targeting MLL degradation pathways in MLL-rearranged leukemia

PROVIDER: PRJNA352353 | ENA |

REPOSITORIES: ENA

Dataset's files

Source:
Action DRS
SRR4880380.fastq.gz Fastqsanger.gz
SRR4880390.fastq.gz Fastqsanger.gz
SRR4880400.fastq.gz Fastqsanger.gz
SRR4880410.fastq.gz Fastqsanger.gz
SRR4880420.fastq.gz Fastqsanger.gz
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Publications


Chromosomal translocations of the mixed-lineage leukemia (MLL) gene with various partner genes result in aggressive leukemia with dismal outcomes. Despite similar expression at the mRNA level from the wild-type and chimeric MLL alleles, the chimeric protein is more stable. We report that UBE2O functions in regulating the stability of wild-type MLL in response to interleukin-1 signaling. Targeting wild-type MLL degradation impedes MLL leukemia cell proliferation, and it downregulates a specific g  ...[more]

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