Genomics

Dataset Information

235

An Argonaute phosphorylation cycle promotes microRNA-mediated silencing


ABSTRACT: An Argonaute phosphorylation cycle promotes microRNA-mediated silencing

PROVIDER: PRJNA354286 | ENA |

REPOSITORIES: ENA

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Publications


MicroRNAs (miRNAs) perform critical functions in normal physiology and disease by associating with Argonaute proteins and downregulating partially complementary messenger RNAs (mRNAs). Here we use clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated protein 9 (Cas9) genome-wide loss-of-function screening coupled with a fluorescent reporter of miRNA activity in human cells to identify new regulators of the miRNA pathway. By using iterative rounds of screening,  ...[more]

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