Genomics

Dataset Information

235

Single cell gene expression in Dlxi1/2b::eGFP+ cells before and after migration


ABSTRACT: Single cell gene expression in Dlxi1/2b::eGFP+ cells before and after migration

PROVIDER: PRJNA378657 | ENA |

REPOSITORIES: ENA

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Publications


The development of the nervous system involves a coordinated succession of events including the migration of GABAergic (γ-aminobutyric-acid-releasing) neurons from ventral to dorsal forebrain and their integration into cortical circuits. However, these interregional interactions have not yet been modelled with human cells. Here we generate three-dimensional spheroids from human pluripotent stem cells that resemble either the dorsal or ventral forebrain and contain cortical glutamatergic or GABAe  ...[more]

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