Genomics

Dataset Information

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PITX1 Promotes Chondrogenesis and Myogenesis in Mouse Hindlimbs Through Conserved Regulatory Targets [ChIP-Seq]


ABSTRACT: PITX1 Promotes Chondrogenesis and Myogenesis in Mouse Hindlimbs Through Conserved Regulatory Targets [ChIP-Seq]

ORGANISM(S): Anolis carolinensis  

PROVIDER: PRJNA412663 | ENA |

REPOSITORIES: ENA

Dataset's files

Source:
Action DRS
SRR6121950.fastq.gz Fastqsanger.gz
SRR6121948.fastq.gz Fastqsanger.gz
SRR6121949.fastq.gz Fastqsanger.gz
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Publications

PITX1 promotes chondrogenesis and myogenesis in mouse hindlimbs through conserved regulatory targets.

Wang Jialiang S JS   Infante Carlos R CR   Park Sungdae S   Menke Douglas B DB  

Developmental biology 20171220 1


The PITX1 transcription factor is expressed during hindlimb development, where it plays a critical role in directing hindlimb growth and the specification of hindlimb morphology. While it is known that PITX1 regulates hindlimb formation, in part, through activation of the Tbx4 gene, other transcriptional targets remain to be elucidated. We have used a combination of ChIP-seq and RNA-seq to investigate enhancer regions and target genes that are directly regulated by PITX1 in embryonic mouse hindl  ...[more]

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