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Gene expression in uninvolved and involved epidermis from patients with atopic dermatitis (laser capture microdissection): set 1

ABSTRACT: Gene expression in uninvolved and involved epidermis from patients with atopic dermatitis (laser capture microdissection): set 1

PROVIDER: PRJNA435727 | ENA |

REPOSITORIES: ENA

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Gene expression in uninvolved and involved epidermis from patients with atopic dermatitis (laser capture microdissection): set 1

Project description:We performed microarray analysis on laser-microdissected epidermis from patients with atopic dermatitis to identify genes dysregulated in uninvolved and involved lesional epidermis

2019-06-30 | GSE111053 | GEO

Gene expression in uninvolved and involved epidermis from patients with atopic dermatitis (laser capture microdissection): set 2

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Gene expression in uninvolved and involved epidermis from patients with atopic dermatitis (laser capture microdissection): set 2

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Gene expression in uninvolved and involved lesional epidermis from human skin biopsies from patients with atopic dermatitis (laser capture microdissection)

Project description:Gene expression in uninvolved and involved lesional epidermis from human skin biopsies from patients with atopic dermatitis (laser capture microdissection)

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Atopic dermatitis epidermis PCT-DIA

Project description:Atopic Dermatitis (AD) is the most common inflammatory skin disease and characterized by a deficient epidermal barrier and cutaneous inflammation. Genetic studies suggest a key role of keratinocytes in AD pathogenesis, but the alterations in the proteome that occur in the entire epidermis have not been defined. Employing a pressure-cycling technology-data-independent acquisition (PCT-DIA) approach, we performed quantitative proteomics of epidermis from healthy volunteers and lesional and non-lesional skin of AD patients. Results were validated by targeted proteomics using parallel reaction monitoring mass spectrometry or by immunofluorescence staining. The identified proteins reflect the strong inflammation in lesional skin and the defect in keratinocyte differentiation and epidermal stratification. Most importantly, they reveal impaired activation of the NRF2-antioxidant pathway and reduced abundance of mitochondrial proteins involved in key metabolic pathways in the epidermis. These results provide insight into the molecular alterations in the epidermis of AD patients and identify novel targets for pharmaceutical intervention.

2022-10-04 | PXD025431 | Pride

Identification of novel immune and barrier genes in atopic dermatitis by means of laser capture microdissection

Project description:This is the first report that establishes robust epidermal and dermal genomic signatures of lesional and nonlesional AD skin and normal skin compared with whole tissues. These data establish the utility of laser capture microdissection to separate different compartments and cellular subsets in patients with AD, allowing localization of key barrier or immune molecules and enabling detection of gene products usually not detected on arrays.

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Gene expression in healthy and lesional psoriatic epidermis from human skin biopsies (laser capture microdissection): set 2

Project description:We performed microarray analysis on laser-microdissected epidermis from healthy volunteers and psoriatic patients to identify genes dysregulated in lesional psoriatic epidermis

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Gene expression in healthy and lesional psoriatic epidermis from human skin biopsies (laser capture microdissection): set 1

2017-06-14 | GSE68923 | GEO

Gene expression in uninvolved and involved lesional epidermis from human skin biopsies from patients with atopic dermatitis (laser capture microdissection)

Project description:This SuperSeries is composed of the SubSeries listed below.

2019-06-30 | GSE111055 | GEO

RNA-Seq of epidermis and mesophyll in arabidopsis developing embryos

Project description:ngs2014_01_microd-ngs micro d-1-RNA seq of epidermis and mesophyll in arabidopsis developing embryos-comparison of transcript accumulation in epidermis and mesophyll in Total RNA extracted by laser assisted microdissection from developping embryos at late heart stage.

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