Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Skin
DISEASE(S): Atopic Dermatitis
SUBMITTER: Ulrich auf dem Keller
LAB HEAD: Ulrich auf dem Keller
PROVIDER: PXD025431 | Pride | 2022-10-04
REPOSITORIES: Pride
The Journal of investigative dermatology 20220913 2
Atopic dermatitis is the most common inflammatory skin disease and is characterized by a deficient epidermal barrier and cutaneous inflammation. Genetic studies suggest a key role of keratinocytes in atopic dermatitis pathogenesis, but the alterations in the proteome that occur in the full epidermis have not been defined. Using a pressure-cycling technology and data-independent acquisition approach, we performed quantitative proteomics of epidermis from healthy volunteers and lesional and nonles ...[more]