Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Expression data for post-bifurcation internal carotid atheroma

ABSTRACT: Expression data for post-bifurcation internal carotid atheroma

PROVIDER: PRJNA438128 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

MicroRNA expression data for post-bifurcation internal carotid atheroma

Project description:MicroRNA expression data for post-bifurcation internal carotid atheroma

| PRJNA438150 | ENA

Expression data for post-bifurcation internal carotid atheroma

Project description:There are regional differences in plaque morphology and mechanistic differences between areas upstream and downstream of the lipid core. Transcript expression profiles were determined for post-bifurcation carotid plaques to identify genes differentially expressed between symptomatic and asymptomatic patients.

2021-03-13 | GSE111782 | GEO

MicroRNA expression data for post-bifurcation internal carotid atheroma

Project description:There are regional differences in plaque morphology and protein expression. MicroRNA expression profiles were determined for post-bifurcation carotid plaques to identify gene regulation mechanisms differentially expressed between symptomatic and asymptomatic patients.

2021-03-13 | GSE111794 | GEO

Genome-wide expression study of human carotid atheroma

Project description:The aim of this study was to identify new biomarkers and to investigate pathways involved in the progression of human carotid atheroma.

2013-04-01 | GSE43292 | GEO

Genome-wide expression study of human carotid atheroma

Project description:The aim of this study was to identify new biomarkers and to investigate pathways involved in the progression of human carotid atheroma. The study was conducted from pieces of carotid endarterectomy collected in 32 hypertensive patients. The samples contained media and neo-intima without adventitia. They were paired, including for each patient one sample of the atheroma plaque (stage IV and over of the Stary classfication) containing core and shoulders of the plaque, and one sample of distant macroscopically intact tissue (stages I and II). In addition, clinical, biological and histological data were collected.

2013-04-01 | E-GEOD-43292 | biostudies-arrayexpress

Genome-wide expression profiling of human carotid atheroma

2013-04-01 | E-MTAB-1470 | biostudies-arrayexpress

RNA expression data from calcified human carotid atherosclerotic plaques

Project description:Although unstable atherosclerosis in the carotid bifurcation is a significant etiology behind ischemic stroke, clinical imaging methods to distinguish stable from vulnerable lesions are lacking and selection of patients for stroke-preventive intervention still relies on surrogate variables with moderate predictive power, such as the degree of luminal narrowing. Here we combined clinical and diagnostic imaging information by comuted tomography to select patients with calcified plaques for large scale molecular analysis, in an effort to increase our understanding of the pathophysiology behind carotid plaque instability as related to patient- and plaque- phenotype.

2019-06-01 | GSE125771 | GEO

Gene Expression in early and advanced atherosclerotic plaque from human carotid

Project description:The objective of this study is to identify genes and pathways involved in the progression of atherosclerotic plaques from early to advanced stage in humans. Samples from atherosclerotic carotid artery segments, from early ((pathological) intimal thickening and intimal xanthoma) and from advanced (thin or thick fibrous cap atheroma) lesions, have been retrieved from the Maastricht Pathology Tissue Collection (MPTC). Tissue was obtained during autopsy (Dept of Pathology, Maastricht University Medical Centre). Collection, storage in the Maastricht Pathology Tissue Collection (MPTC) and use of tissue and patient data were performed in agreement with the "Code for Proper Secondary Use of Human Tissue"

2011-04-25 | E-GEOD-28829 | biostudies-arrayexpress

Proteomic analysis of distinct regions of human carotid atherosclerotic plaques

Project description:Protein profiles were determined from different distinct regions of human atherosclerotic plaques, including: internal control, fatty streak, plaque shoulder, plaque centre, and fibrous cap. Protein extracts from all 5 regions, from 3 men and 3 women, were separated by two-dimensional gel electrophoresis (in total 30 2-DE gels). Stained gels were matched by protein spot distribution, and a protein mapping was performed to identify as many protein spots as possible, by MALDI-TOF MS / peptide mass fingerprinting (Voyager DE Pro; Applied Biosystems). This resulted in the identification of 97 protein spots, corresponding to 52 unique protein by accession number. To expand on this nLC-MS/MS (Easy-nLC / LTQ Orbitrap Velos Pro; Thermo Fisher Scientific) experiments were run on additional carotid plaque samples from 10 men and 10 women, using three of the predefined regions; internal control, fatty streak, plaque core. MS/MS analysis resulted in the identification of over 1000 proteins. Human carotid atherosclerotic plaques (n = 26) were obtained from the Linköping Carotid Study, and all methods/protocols described herein have been approved by the local ethics committee (Linköping University Hospital, Linköping, Sweden). Written informed consent was also obtained from all patients.

2016-05-24 | PXD003930 | Pride

Deep-sequencing of endothelial-enriched RNAs from carotid arteries of C57 Bl6 mice subjected to partial carotid ligation (PCL) to determine the effect of disturbed blood flow and aging

Project description:Purpose: To determine the effect of disturbed blood flow and aging on mouse carotid artery endothelial cells. Methods: 8-week old and 80-week-old male C57BL6 mice were subjected to partial carotid ligation surgery and two days post ligation surgery, the endothelial enriched RNAs were flushed out using Qiazol

2024-02-07 | GSE197366 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data