Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Gene Expression Profiling of Estrogen Signaling in Colon Cancer Cell Line

ABSTRACT: Gene Expression Profiling of Estrogen Signaling in Colon Cancer Cell Line

PROVIDER: PRJNA448189 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Gene Expression Profiling of Estrogen Signaling in Colon Cancer Cell Line [CRC Project]

Project description:Gene Expression Profiling of Estrogen Signaling in Colon Cancer Cell Line [CRC Project]

| PRJNA448191 | ENA

Gene Expression Profiling of Estrogen Signaling in Colon Cancer Cell Line [CRC Project_addendum]

Project description:Gene Expression Profiling of Estrogen Signaling in Colon Cancer Cell Line [CRC Project_addendum]

| PRJNA448193 | ENA

Gene Expression Profiling of Estrogen Signaling in Colon Cancer Cell Line [CRC Project]

Project description:We studied the transcriptional effect of estrogen in two colon cancer cell lines SW620 and SW480

2021-03-05 | GSE112565 | GEO

Gene Expression Profiling of Estrogen Signaling in Colon Cancer Cell Line [CRC Project_addendum]

Project description:We studied the transcriptional effect of estrogen, G1, and ICI in two colon cancer cell lines SW620 and SW480

2021-03-05 | GSE112568 | GEO

Estrogen signaling modulates the colon microenvironment during obesity

Project description:Estrogen signaling modulates the colon microenvironment during obesity

| PRJNA630214 | ENA

Estrogen signaling modulates the colon microenvironment during obesity

Project description:Epidemiological studies highlight a strong association between obesity and colorectal cancer (CRC). This association appears stronger in men and a role for sex hormones is indicated by epidemiological studies. Especially estrogen is protective against CRC and correlated to several aspects of the metabolic syndrome. Anti-inflammatory and anti-tumorigenic effects of estrogen in colon have been demonstrated to act via estrogen receptor beta (ERβ). This led us to hypothesize that estrogenic signaling, through both systemic and local effects might modulate the colon microenvironment during HFD-induced obesity. In order to test our hypothesis mice were fed a control diet or a high fat diet (HFD) for 3 weeks and treated with different estrogenic ligands. In the present study, we demonstrate that there are sex-differences in the response to HFD-induced obesity and in the colon transcriptome. Both sexes develop obesity with an impaired circadian rhythm but the male metabolic profile is more sensitive to HFD and increased the colon epithelial cell proliferation. Females were resistant to impaired glucose metabolism, but HFD-feeding increased the infiltration of macrophages. Estrogen signaling in males, via ERα, presented anti-obesogenic effects. However, systemic and/or local activation of both ERα and ERβ restored the circadian rhythm in the males. In females, systemic activation of ERα restored the circadian rhythm, however, systemic and/or local activation of ERβ down-regulated the expression of macrophage markers. These results suggest that estrogen signaling through systemic and/or local activation of ERβ can regulate the colon microenvironment during HFD-induced obesity.

2020-10-07 | GSE149811 | GEO

Transcription profiling of human colon cancer cell line SW480 expressing ERb and then treated with estrogen or untreated

Project description:Assess the full impact of estrogen receptor beta on transcription by a full transcriptome analysis of ERb-mediated gene regulation in the SW480 colon cancer cell line. The colon cancer cell line SW480 does not express endogenous ER but is made ERb-expressing by lentiviral transduction of an ERb expression cassette. Introduction of ERb makes it possible to study the role and function of ERb in colon cancer as well as the impact ERb has on its own (in the absence of ERa).

2011-02-18 | E-MEXP-1473 | biostudies-arrayexpress

GPR30-mediated estrogen signaling in Estrogen Receptor alpha and beta negative SKBR3 breast cancer cells

Project description:Gene expression analyses were carried out to identify genes regulated by 17-beta estradiol (E2) and Hydroxytamoxifen (OHT) through GPR30 in SKBR3 cells, a breast cancer cell-line which expresses GPR30 but lacks Estrogen Receptor alpha or beta. Keywords: Gene expression analysis, Non-genomic signaling in breast cancer cells.

2009-02-19 | GSE11567 | GEO

ARID1A modules estrogen receptor signaling in endometrial cancer

Project description:ARID1A modules estrogen receptor signaling in endometrial cancer

| PRJNA613673 | ENA

Comparison of monoculture to coculture colon cancer cell-line generated spheroids

Project description:Chromatogram library generated of pooled sample. Coculture spheroids formed from fibroblast and colon cancer cell lines, and monoculture spheroids formed from the colon cancer cell line HCT116.

2023-11-13 | MSV000093395 | MassIVE

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data