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Molecular characterization of acral melanoma

ABSTRACT: Molecular characterization of acral melanoma

PROVIDER: PRJNA471578 | ENA |

REPOSITORIES: ENA

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Molecular characterization of acral melanoma

Project description:Molecular characterization of acral melanoma

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Genome wide analysis of acral melanoma

Project description:This SuperSeries is composed of the following subset Series: GSE28909: Genome wide analysis of acral melanoma (Illumina) GSE28910: Genome wide analysis of acral melanoma (Affymetrix) Refer to individual Series

2011-12-13 | E-GEOD-28913 | biostudies-arrayexpress

Genome wide analysis of acral melanoma (Affymetrix)

Project description:Genotyping of a matched normal, primary and metastatic acral melanoma DNA from blood and one matched Primary and one metastatic acral melanoma was genotyped on Affmetrix SNP6

2011-12-13 | E-GEOD-28910 | biostudies-arrayexpress

Genome wide analysis of acral melanoma (Illumina)

Project description:Assessment of mutation on expression levels Transcriptomic profile of a matched primary and metastatic acral melanoma One Primary and one metastatic acral melanoma transcript expression were assayed (no matched normal)

2011-12-13 | E-GEOD-28909 | biostudies-arrayexpress

Single cell characterization of the cellular landscape of acral melanoma identifies novel targets for immunotherapy

Project description:Acral melanoma is a rare subtype of melanoma that arises on the non-hair-bearing skin of the palms, soles and nail beds. In this study, we used single cell RNA-seq (scRNA-seq) to map the transcriptional landscape of acral melanoma and identify novel immunotherapeutic targets.

2022-02-14 | GSE189889 | GEO

Genome wide analysis of acral melanoma (Affymetrix)

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Integrative molecular and clinical profiling of acral melanoma links focal amplification of chr22q11.21 to metastasis

Project description:Acral melanoma, the most common melanoma subtype among non-Caucasian individuals, is associated with poor prognosis. However, its key molecular drivers remain obscure. Here, we perform integrative genomic and clinical profiling of acral melanomas from a cohort of 104 patients treated in North America or China. We find that recurrent, late-arising amplifications of cytoband chr22q11.21 are a leading determinant of inferior survival, strongly associated with metastasis, and linked to downregulation of immunomodulatory genes associated with response to immune checkpoint blockade. Unexpectedly, LZTR1 – a known tumor suppressor in other cancers – is a key candidate oncogene in this cytoband. Silencing of LZTR1 in melanoma cell lines caused apoptotic cell death independent of major hotspot mutations or melanoma subtypes. Conversely, overexpression of LZTR1 in normal human melanocytes initiated processes associated with metastasis, including anchorage-independent growth, formation of spheroids, and increased levels of MAPK and SRC activities. Our results provide insights into the etiology of acral melanoma and implicate LZTR1 as a key tumor promoter and therapeutic target.

2021-12-14 | GSE189341 | GEO

Genome wide analysis of acral melanoma (Illumina)

Project description:Assessment of mutation on expression levels Transcriptomic profile of a matched primary and metastatic acral melanoma

2011-12-13 | GSE28909 | GEO

Integrative Molecular and Clinical Profiling of Acral Melanoma Identifies LZTR1 as a Key Tumor Promoter and Therapeutic Target

Project description:Acral melanoma, the most common melanoma subtype among non-Caucasian individuals, is associated with poor prognosis. However, its key molecular drivers remain obscure. Here, we performed integrative genomic and clinical profiling of acral melanomas from a cohort of 104 patients treated in North America or China. We found that recurrent, late-arising amplifications of cytoband chr22q11.21 are a leading determinant of inferior survival, strongly associated with metastasis, and linked to downregulation of immunomodulatory genes associated with response to immune checkpoint blockade. Unexpectedly, LZTR1 – a known tumor suppressor in other cancers – is a key candidate oncogene in this cytoband. Silencing of LZTR1 in melanoma cell lines caused apoptotic cell death independent of major hotspot mutations or melanoma subtypes. Conversely, overexpression of LZTR1 in normal human melanocytes initiated processes associated with metastasis, including anchorage-independent growth, formation of spheroids, and increased levels of MAPK and SRC activities. Our results provide new insights into the etiology of acral melanoma and implicate LZTR1 as a key tumor promoter and therapeutic target. Keywords: Expression profiling by high throughput sequencing

2021-12-14 | GSE190113 | GEO

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