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Nuclear actin is required for transcription during Drosophila oogenesis

ABSTRACT: Nuclear actin is required for transcription during Drosophila oogenesis

PROVIDER: PRJNA478253 | ENA |

REPOSITORIES: ENA

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Nuclear actin is required for transcription during Drosophila oogenesis [RNA-seq]

Project description:Nuclear actin is required for transcription during Drosophila oogenesis [RNA-seq]

| PRJNA478255 | ENA

Nuclear actin is required for transcription during Drosophila oogenesis [ChIP-seq]

Project description:Nuclear actin is required for transcription during Drosophila oogenesis [ChIP-seq]

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Nuclear actin is required for transcription during Drosophila oogenesis [ChIP-seq]

Project description:We demonstrate that actin interacts with essentially all transcribed genes and co-occupies most gene promoters together with RNA polymerase II (Pol II). On highly expressed genes, actin and Pol II can be found also on the gene bodies.

2018-08-01 | GSE116362 | GEO

Nuclear actin activates human transcription factor genes including the OCT4 gene

Project description:RNA microarray analyses revealed that nuclear actin activated many human transcription factor genes including OCT4, which is required for gene reprogramming. OCT4 is known to be activated by nuclear actin in Xenopus oocytes. Our findings imply that this process of OCT4 activation is conserved in vertebrates and among cell types, and could be used for gene reprogramming of human cells.

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Nuclear Actin Is Required for Transcription during Drosophila Oogenesis.

Project description: Not available

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RASSF1A IS REQUIRED FOR THE MAINTENANCE OF NUCLEAR ACTIN LEVELS

Project description:Nuclear actin participates in many essential cellular processes including gene transcription, chromatic remodelling and mRNA processing. Actin shuttles into and out the nucleus through the action of dedicated transport receptors importin-9 and exportin-6, but how this transport is regulated remains unclear. Here we show that RASSF1A is a novel regulator of actin nucleocytoplasmic trafficking and is required for the active maintenance of nuclear actin levels through supporting binding of exportin-6 (XPO6) to RAN GTPase. RASSF1A (Ras association domain family 1 isoform A) is a tumor suppressor gene frequently silenced by promoter hypermethylation in all major solid cancers. Specifically, we demonstrate that endogenous RASSF1A localizes to the nuclear envelope (NE) and is required for nucleo-cytoplasmic actin transport and the concomitant regulation of Myocardin-related transcription factor A (MRTF-A), a coactivator of the transcription factor serum response factor (SRF). The RASSF1A/RAN/XPO6/nuclear actin pathway is aberrant in cancer cells where RASSF1A expression is lost and correlates with reduced MTRF/SRF activity leading to cell adhesion defects. Taken together, we have identified a previously unknown mechanism by which the nuclear actin pool is regulated and uncovered a previously unknown link of RASSF1A and MTRF/SRF in tumor suppression.

2019-05-30 | PXD011517 | Pride

Nuclear actin is required for transcription during Drosophila oogenesis

Project description:This SuperSeries is composed of the SubSeries listed below.

2018-08-01 | GSE116365 | GEO

Polycomb function during oogenesis is required for mouse early embryonic development

Project description:This SuperSeries is composed of the following subset Series: GSE23033: Polycomb function during oogenesis is required for mouse early embryonic development (germinal vesicle oocytes) GSE28710: Polycomb function during oogenesis is required for mouse early embryonic development (2-cell embryos) Refer to individual Series

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T cell receptor-triggered nuclear actin network formation drives CD4 T cell effector functions

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Nuclear actin is required for transcription during Drosophila oogenesis [RNA-seq]

Project description:we performed transcriptomic analysis of the RanBP9del1 mutant ovaries compared to wild type

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