Genomics

Dataset Information

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CD73 knockdown effect in pancreatic cancer cell lines


ABSTRACT: CD73 knockdown effect in pancreatic cancer cell lines

PROVIDER: PRJNA480855 | ENA |

REPOSITORIES: ENA

Dataset's files

Source:
Action DRS
SRR7515480_1.fastq.gz Fastqsanger.gz
SRR7515480_2.fastq.gz Fastqsanger.gz
SRR7515475_1.fastq.gz Fastqsanger.gz
SRR7515475_2.fastq.gz Fastqsanger.gz
SRR7515476_1.fastq.gz Fastqsanger.gz
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Publications

The distinct role of CD73 in the progression of pancreatic cancer.

Zhou Liangjing L   Jia Shengnan S   Chen Yan Y   Wang Weiming W   Wu Zhengrong Z   Yu Weihua W   Zhang Mingjie M   Ding Guoping G   Cao Liping L  

Journal of molecular medicine (Berlin, Germany) 20190329 6


Recent studies have shown that the non-enzymatic function of CD73 plays a key role in tumor progression, but this function of CD73 in pancreatic cancer cells has not been studied. Furthermore, little is known about the mechanism involved in CD73 regulation in tumors. Here, we found that CD73 expression was upregulated in pancreatic ductal adenocarcinoma (PDAC) and that its expression correlated with poor prognosis. CD73 knockdown inhibited cell growth and induced G1 phase arrest via the AKT/ERK/  ...[more]

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