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Echinacea purpurea elicits anti-viral response in THP-1 monocytes through activation of interferon, MAPK and NF-κB signaling pathways and DNA hypermethylation of repeat elements

ABSTRACT: Echinacea purpurea elicits anti-viral response in THP-1 monocytes through activation of interferon, MAPK and NF-κB signaling pathways and DNA hypermethylation of repeat elements

PROVIDER: PRJNA483543 | ENA |

REPOSITORIES: ENA

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Echinacea purpurea elicits anti-viral response in THP-1 monocytes through activation of interferon, MAPK and NF-κB signaling pathways and DNA hypermethylation of repeat elements

Project description:This SuperSeries is composed of the SubSeries listed below.

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Subtracted Diversity Array identifies novel molecular markers including retrotransposons for fingerprinting Echinacea species

Project description:Echinacea, native to the Canadian prairies and the prairie states of the United States, has a long tradition as a folk medicine for the Native Americans. Currently, Echinacea are among the top 10 selling herbal medicines in the U.S. and Europe, due to increasing popularity for the treatment of common cold and ability to stimulate the immune system. However, the genetic relationships within the species of this genus are unclear, which makes difficult the authentication of the species used for the medicinal industry. We report the construction of a novel Subtracted Diversity Array (SDA) for Echinacea species and demonstrate the potential of this array for isolating highly polymorphic sequences. In order to selectively isolate Echinacea-specific sequences, a Suppression Subtractive Hybridization (SSH) was performed between a pool of twenty-four Echinacea genotypes and a pool of other angiosperms and non-angiosperms. A total of 283 subtracted genomic DNA (gDNA) fragments were amplified and arrayed. Twenty-seven Echinacea genotypes, including four that were not used in the array construction, could be successfully discriminated. Interestingly, unknown samples of E. paradoxa and E. purpurea could be unambiguously identified from the cluster analysis. Furthermore, this Echinacea-specific SDA was also able to isolate highly polymorphic sequences. Five out of the eleven most discriminatory features matched to known retrotransposons.

2013-12-31 | E-GEOD-44683 | biostudies-arrayexpress

Subtracted Diversity Array identifies novel molecular markers including retrotransposons for fingerprinting Echinacea species

2013-12-31 | GSE44683 | GEO

Human dendritic cells treated with Echinacea purpurea phytocompounds

Project description:This study investigated the specific and differential gene expression in human immature DCs (iDCs) in response to treatment with a butanol fraction containing defined bioactive phytocompounds extracted from stems and leaves of Echinacea purpurea

2008-09-10 | GSE12259 | GEO

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Project description:Echinacea purpurea Transcriptome or Gene expression

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Stimulatory effect of Echinacea purpurea extract on trafficking activity in mouse dendritic cells

Project description:To seek scientific evidence supporting therapeutic use of Echinacea, the transcriptomic effects of Echinacea purpurea extract on mouse bone marrow-derived dendritic cells (BMDCs) were analyzed using primary cultures. Affymetrix DNA microarray and bioinformatics analyses of genes differentially expressed in DCs treated with [BF/S+L/Ep] for 4 or 12 h revealed that the majority of responsive genes were related to cell adhesion or motility (Cdh10, Itga6, Cdh1, Gja1 and Mmp8), or were chemokines (Cxcl2, Cxcl7) or signaling molecules (Nrxn1, Pkce and Acss1).

2010-09-13 | GSE19369 | GEO

Transcription profiling of mouse dendritic cells reveals stimulatory effect of Echinacea purpurea extract on trafficking activity

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