Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Transcriptomics analysis of gene expression in mouse lung after PM2.5 exposure

ABSTRACT: Transcriptomics analysis of gene expression in mouse lung after PM2.5 exposure

PROVIDER: PRJNA505421 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

m5C profiles in mouse lung after PM2.5 exposure

Project description:m5C profiles in mouse lung after PM2.5 exposure

| PRJNA505419 | ENA

Transcriptomics reveals the cytotoxicity of PM2.5 to mouse spermatocyte-derived GC-2spd cells

Project description:We have found that PM2.5 exposure can induce spermatocyte damage and inhibit GC-2spd cell proliferation in vivo and vitro studies. Transcriptomics was performed to explore the potential mechanism of PM2.5-induced reproductive toxicity. With RNA-sequencing technique, the differentially expressed genes induced by PM2.5 exposure were mainly enriched in the metabolism of xenobiotics by cytochrome P450 pathway, and Cyp1a1 was the most significantly changed gene.

2021-12-16 | GSE189187 | GEO

HT-Seq analysis of mouse lung after PM2.5 exposure

Project description:HT-Seq analysis of mouse lung after PM2.5 exposure

| PRJNA505422 | ENA

Transcriptomics profiles in human keratinocytes after PM2.5 exposure

Project description:Transcriptomics profiles in human keratinocytes after PM2.5 exposure

| PRJNA601422 | ENA

Effect of PM2.5-treated and TMPRSS2-overexpressed on gene expression in lung cancer cells

Project description:Lung cancer cells exposed to PM2.5 for 90 days or overexpressed TMPRSS2 were employed as a cellular model to evaluate the effects of long-term exposure to PM2.5 on lung cancer progression.

2023-05-23 | GSE220252 | GEO

Effect of PM2.5-treatment and TMPRSS2-overexpression on gene expression in lung cancer cells

2023-05-23 | GSE220306 | GEO

Effect of Pre- and Postnatal Exposure to urban PM2.5 on the Transcriptome of the Developing and Early-Life Mouse Lung

Project description:Over the last years, evidence has grown that exposure to air pollution, in addition to impairing lung function and health in individuals of all age, can be linked to negative effects in newborn when present during pregnancy. Data suggests that intrauterine exposure of fetuses (exposure of the mother to air pollution during pregnancy) in fact exerts a negative impact on lung development. However, the means by which exposure during pregnancy affects lung development, have not been studied in depth yet. In this study, we investigated alterations of the transcriptome of the developing lung in a mouse model of gestational and early-life postnatal exposure to urban PM2.5 (from Sao Paulo, Brazil).

2018-06-08 | GSE104656 | GEO

PM2.5 exposure induces lifespan reduction in Caenorhabditis elegans

Project description:To elucidate the molecular mechanism underlying lifespan reduction induced by PM2.5 exposure in Caenorhabditis elegans, we performed global gene expression profiling by RNA-sequencing technology, and compared the gene expression pattern change induced by PM2.5 exposure.

2023-02-22 | GSE214215 | GEO

Yangyinqingfei Decoction attenuates PM2.5-induced lung injury by enhancing arachidonic acid metabolism

Project description:Yangyinqingfei Decoction (YYQFD), a traditional Chinese prescription, is well known in the treatment of diphtheria and lung-related diseases in clinic. However, the underlying mechanism how to treat lung-related diseases remains unclear. In the present study, the intervention effect of YYQFD on PM2.5-induced lung injury mice and its potential mechanism were investigated by metabolomics and proteomic techniques. The results showed that YYQFD could significantly improve pulmonary functions, relieve lung injury, as well as reduce IL-6, TNF-α and MDA, and increase SOD levels in serum and BALF of PM2.5-induced lung injury mice. Furthermore, the protein-metabolite joint analysis presented that YYQFD regulated the pathways of arachidonic acid metabolism, linoleic acid metabolism, and biosynthesis of unsaturated fatty acids with significantly down-regulating arachidonic acid, 20-HETE, prostaglandin E2, lecithin, linoleic acid, α-linolenic acid, eicosatetraenoic acid, and γ-linolenic acid, and up-regulating PTGES2, GPX2 and CBR3 protein expressions in lung tissue. A regulatory metabolic network map was further constructed, which provide us a better understanding about the role of YYQFD on PM2.5-induced lung injury mice and new insight into YYQFD application for the treatment of lung-related diseases.

2022-12-22 | PXD037163 | Pride

Transcriptomics profiles in human keratinocytes after PM2.5 exposure

Project description:RNA-seq in normal human epidermal keratinocytes (NHEK) for understanding PM2.5-induced effects

2022-06-22 | GSE143709 | GEO