Project description:We have found that PM2.5 exposure can induce spermatocyte damage and inhibit GC-2spd cell proliferation in vivo and vitro studies. Transcriptomics was performed to explore the potential mechanism of PM2.5-induced reproductive toxicity. With RNA-sequencing technique, the differentially expressed genes induced by PM2.5 exposure were mainly enriched in the metabolism of xenobiotics by cytochrome P450 pathway, and Cyp1a1 was the most significantly changed gene.
Project description:To elucidate the molecular mechanism underlying lifespan reduction induced by PM2.5 exposure in Caenorhabditis elegans, we performed global gene expression profiling by RNA-sequencing technology, and compared the gene expression pattern change induced by PM2.5 exposure.
Project description:In this study, we performed high-throughput sequencing to evaluate the gene expression profiles of Human Nasal Epithelial Cells (HNEpC) (C-12620, PromoCell, Heidelberg, Germany) after exposure to PM2.5 for 24 hours.
Project description:Exposure to PM2.5 affects gene expression of BEAS-2B cells Gene expression microarrays were used to detail changes in the transcriptome upon exposure to PM2.5
Project description:Genome-wide analysis of lncRNA expression profiles in COPD rat model exposed by cigarette smoking (CS) and fine particulate matter (PM2.5). Goal was to explore the differences and similarities lncRNAs expression in rats model of COPD exposed by CS and PM2.5.
Project description:We report the application of Ribosome sequencing for high-throughput profiling of tanslation efficiency in BEAS-2B cells after exposure to PM2.5.