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Gene expression data from human primary cultured Schwann cells

ABSTRACT: Gene expression data from human primary cultured Schwann cells

PROVIDER: PRJNA520846 | ENA |

REPOSITORIES: ENA

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Gene expression data from human primary cultured Schwann cells

Project description:Schwann cells undergo reprogramming after nerve injury, switching to immature repair phenotype. The goal was to test what genetic perturbations are triggered in Schwann cells with the stimulus from melanoma cell secreted factors. We used microarrays to detail the changes in gene expression of Schwann cells treated with human melanoma conditioned medium.

2019-02-05 | GSE126040 | GEO

Effect of live Mycobacterium leprae on primary human Schwann cell gene expression

Project description:In attempt to understand M.leprae interaction with the human host, Applied Biosystems microarrays containing 30,865 probles were used to identify modulated genes in primary human Schwann Cells (SC) infected with live M. leprae at two early time points, 24 and 48 hours. A total of 4 independent experimental samples were prepared which were hybridized to two replicate microarrays each.The four experimental samples included both uninfected and M. leprae infected Schwann cells at both 24 and 48 hours.

2012-06-30 | E-GEOD-35423 | biostudies-arrayexpress

Effect of live Mycobacterium leprae on primary human Schwann cell gene expression

2012-07-01 | GSE35423 | GEO

Effect of live Mycobacterium leprae infection on global gene expression of primary human Schwann cells at 24 hours

Project description:In an attempt to understand M. leprae interaction with the human host, Stanford Genomics HEEBO Arrays were use to identify modulated genes in primary human Schwann cells infected with live M. leprae at a MOI of 100:1 for 24 hours. Dual channel competitive hybridizations between M. leprae infected and non infected Schwann cells including 3 independent biological replicates and a technical replicate in the form of dye swap.

2013-01-03 | E-GEOD-40950 | biostudies-arrayexpress

Comparison of C3 or C3156-181-peptide treated Isolated primary rat neonatal Schwann Cells after 12 h

Project description:The aim of this study was to identify differently expressed genes between C3 or C3156-181-peptide treated Isolated primary rat neonatal Schwann Cells. To elucidate the unresolved mechanism behind the promoting effect of C3156-181 on PNR we cultured primary rat neonatal SCs and treated them for up to 72 h with C3 or C3156-181. We then performed gene expression microarray analysis Results from two loops of two different treatment times are summarized in this study. The samples were taken from two C3 or C3156-181-peptide treated Isolated primary rat neonatal Schwann Cell cultures. Microarrays were hybridized in a loop approach. Results from two loops that map to two different sampling times (loop1: after 12 hours, loop2: after 72) are compared in this study. The data in this file represents loop1. The samples were taken from untreated, C3 or C3156-181-peptide treated Isolated primary rat neonatal Schwann Cells.

2015-07-11 | E-GEOD-70747 | biostudies-arrayexpress

Effect of live Mycobacterium leprae infection on global gene expression of primary human Schwann cells at 24 hours

2013-01-03 | GSE40950 | GEO

Comparison of C3 or C3156-181-peptide treated Isolated primary rat neonatal Schwann Cells after 12 h

2015-07-11 | GSE70747 | GEO

Gene expression changes induced by ILB in Schwann like cells

Project description:To understand the mechanism of action of ILB we have used gene expression analysis to document the changes induced by the drug in Schwann like cells. Human Schwann-like cells (ATCC-CRL-2884) were treated with ILB (0.01 mg/ml) for 48 hours. Control samples were cultured parallel with no drug added. The expression data was used to identify the ILB-regulated genes.

2020-06-25 | GSE153199 | GEO

Direct genesis of functional rodent and human Schwann cells from skin mesenchymal precursors (rat)

Project description:Recent reports of directed reprogramming have raised questions about the stability of cell lineages. Here, we have addressed this issue, focusing upon skin-derived precursors (SKPs), a dermally-derived precursor cell. We show by lineage tracing that murine SKPs from dorsal skin originate from mesenchymal and not neural crest-derived cells. These mesenchymally-derived SKPs can, without genetic manipulation, generate functional Schwann cells, a neural crest cell type, and are highly similar at the transcriptional level to Schwann cells isolated from the peripheral nerve. This is not a mouse-specific phenomenon, since human SKPs that are highly similar at the transcriptome level can be made from facial (neural crest-derived) and foreskin (mesodermally-derived) dermis, and the mesodermally-derived SKPs can make myelinating Schwann cells. Thus, non-neural crest-derived mesenchymal precursors can differentiate into bona fide peripheral glia in the absence of genetic manipulation, suggesting that developmentally-defined lineage boundaries are more flexible than widely thought. We obtained 3 independent samples of nerve Schwann cells, SKP-derived Schwann cells, and Dorsal Trunk SKPs, each, from adult SD rats. Primary cells were isolated and cultured, and RNA was collected from those cultured samples. RNA samples deriving from these cells were analyzed on the Affymetrix Rat Gene 1.0 ST Array.

2014-08-01 | E-GEOD-57505 | biostudies-arrayexpress

Chemical conversion of human fibroblasts into functional Schwann cells

Project description:We used microarrays to detail the transcriptome-wide gene expression changes underlying chemical conversion of human fibroblasts into induced Schwann Cells over a time period of 39 days. We compared then the expression profiles of these induced Schwann Cells to primary Schwann cells. The gene expression results analyzed in this study are further described in Thoma et al. (2014) Chemical conversion of human fibroblasts into functional Schwann cells. Under submission

2014-12-01 | GSE59125 | GEO

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