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Whsc1 controls mesendodermal transcription factor expression

ABSTRACT: Whsc1 controls mesendodermal transcription factor expression

PROVIDER: PRJNA522735 | ENA |

REPOSITORIES: ENA

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Whsc1 controls mesendodermal transcription factor expression

Project description:We report here chromatin related factor Whsc1 links pluripotency exit and mesendodermal differentiation. We performed RNA-seqs to compare Whsc1+/+ and Whsc1-/- embryonic stem cells (ESCs) to compare the transcriptomes. UMI-4C experiments have been performed to identify regions having contacts with promoter regions of downstream Whsc1 targets: the mesendoderm transcritpion factors

2019-06-20 | GSE126618 | GEO

Analysis of Wild Type and Whsc1-/- small intestine Transcriptomes

Project description:Histone dimethyl transferase WHSC1 drives the transcription of MHC-I machinery in mouse and human colorectal cancer cells (CRCs); thus, WHSC1 downregulation potentiates CRCs to escape from cytotoxic CD8+ T cell responses. WHSC1 directly interacts with MHC-I transactivator, NLRC5 to selectively stimulate MHC-I gene expression. Thus, silencing Whsc1 diminished MHC-I level, impaired anti-tumor immunity and blunted immunotherapy efficacy.

2022-03-25 | GSE179472 | GEO

Transcription factor HESX1 enhances mesendodermal commitment of human embryonic stem cells by modulating ERK1/2 signaling

Project description:Transcription factor HESX1 enhances mesendodermal commitment of human embryonic stem cells by modulating ERK1/2 signaling

| PRJNA818864 | ENA

WHSC1/NSD2 regulates immune infiltration in prostate cancer [ATAC-Seq]

Project description:the WHSC1 enzymes controls immune infiltration in prostate cancer by regulating the expression of genes in immune pathways and genes in the antigen processng and presentation machinery

2020-12-11 | GSE153335 | GEO

WHSC1/NSD2 regulates immune infiltration in prostate cancer [RNA-Seq]

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Genome-wide maps of chromatin state in WT and Whsc1 ko or Nlrc5 ko CT26 cells.

2022-03-25 | GSE179467 | GEO

The NAC transcription factor FaRIF controls fruit ripening in strawberry

Project description:The NAC transcription factor FaRIF controls fruit ripening in strawberry

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SUMOylation controls the neurodevelopmental function of the transcription factor Zbtb20

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Genome-wide maps of chromatin state in WT and Whsc1 ko or Nlrc5 ko CT26 cells [ATAC-seq]

2022-01-03 | GSE192672 | GEO

Transcription factor HESX1 enhances mesendodermal commitment of human embryonic stem cells by modulating ERK1/2 signaling

Project description:Transcription factors are key determinants of lineage commitment during mammalian development. However, the function and molecular mechanism for the transcription factors in the formation of three primary germ layers during human embryonic development are not fully elucidated. Here, we report that homeobox-containing transcription factor HESX1 plays a critical role in mesendodermal (ME) commitment of human embryonic stem cells (hESCs). Our results show that expression of HESX1 in hESCs is regulated by OCT4 and NANOG, and that its expression level changes with hESC differentiation. We find that knockdown of HESX1 does not disrupt the undifferentiated state of hESCs, in terms of cell morphology and expression levels of pluripotency- associated genes. However, HESX1 deficiency in hESCs impairs their ME commitment, whereas forced expression of HESX1 significantly enhances ME marker expression during ME commitment. Interestingly, HESX1 knockdown in hESCs represses ERK1/2 signaling activated by ME induction, while overexpression of HESX1 markedly enhances ERK1/2 activity during ME commitment of hESCs. Of note, MEK inhibitor PD0325901 weakens or even eliminates HESX1 overexpression- mediated promotive effects on ME induction in a dosage- dependent manner. Together, this study identifies a novel role of HESX1 in hESC commitment to ME cells and establishes the functional link between a transcription factor and lineage- associated signaling. These findings would help to better understand early human development and develop more efficient protocols to induce hESC differentiation to desired lineages.

2022-06-10 | GSE199196 | GEO

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