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Wound epidermis-dependent transcriptional programs

ABSTRACT: Wound epidermis-dependent transcriptional programs

PROVIDER: PRJNA547594 | ENA |

REPOSITORIES: ENA

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Wound epidermis-dependent transcriptional programs

Project description:The wound epidermis is required for limb regeneration. To elucidate the roles of the wound epidermis during early regeneration, we examined how the transcriptional programs of early dividing cells (enriched for blastemal progenitors) and non-dividing cells in regenerating stump tissues as well as epithelial cells change when we prevented wound epidermis formation.

2020-01-15 | GSE132317 | GEO

Defining stem cell dynamics and migration during wound healing in mouse skin epidermis (D4 post-wound)

Project description:Wound healing is essential to repair the skin after injury. In the epidermis, distinct stem cells (SCs) populations contribute to wound healing. However, how SCs balance proliferation, differentiation and migration to repair a wound remains poorly understood. Here we show the cellular and molecular mechanisms that regulate wound healing in mouse tail epidermis. Using a combination of proliferation kinetics experiments and molecular profiling, we identify the gene signatures associated with proliferation, differentiation and migration in different regions surrounding the wound. Functional experiments show that SC proliferation, migration and differentiation can be uncoupled during wound healing. Lineage tracing and quantitative clonal analysis reveal that, following wounding, progenitors divide more rapidly, but conserve their homeostatic mode of division, leading to their rapid depletion whereas SCs become active, giving rise to new progenitors that expand and repair the wound. These results have important implications for tissue regeneration, acute and chronic wound disorders.

2017-02-28 | GSE93638 | GEO

Novel Foxo1-dependent Transcriptional Programs Control Treg Cell Function

Project description:This SuperSeries is composed of the following subset Series: GSE40655: Novel Foxo1-dependent Transcriptional Programs Control Treg Cell Function [Affymetrix gene expression data] GSE40656: Novel Foxo1-dependent Transcriptional Programs Control Treg Cell Function [ChIP-Seq] Refer to individual Series

2012-09-07 | E-GEOD-40657 | biostudies-arrayexpress

Defining stem cell dynamics and migration during wound healing in mouse skin epidermis

2017-02-28 | GSE76795 | GEO

Transcriptional programming of human epidermis during wound repair and in pressure ulcer at single-cell resolution

Project description:Transcriptional programming of human epidermis during wound repair and in pressure ulcer at single-cell resolution

| PRJNA573734 | ENA

Phosphatidylinositol-3-kinase p110 delta differentially restrains and directs naïve versus effector CD8+ T cell transcriptional programs Phosphatidylinositol-3-kinase p110 delta differentially restrains and directs naïve versus effector CD8+ T cell transcriptional programs

Project description:Phosphatidylinositol-3-kinase p110 delta (PI3Kp110δ) is pivotal for CD8+ T cell immune responses. To inform how PI3Kp110δ regulates CD8+ T cells, the current study focuses on PI3Kp110δ controlled transcriptional programs and reveals how PI3Kp110δ selectively induces and represses expression of key genes that create a cytotoxic T cell (CTL). The data identify differences in PI3Kp110δ regulated transcriptional programs between naïve and cytotoxic T cells including differential control of cytolytic effector molecules, costimulatory receptors and the critical inhibitory receptors CTLA4 and SLAMF6. However, common to both naïve and effector cells is PI3Kp110δ control of the production of chemokines and cytokines that orchestrate communication between the adaptive and innate immune system. The study provides a comprehensive resource for understanding how PI3Kp110δ uses multiple mechanisms dependent on Protein Kinase B/AKT, FOXO1 dependent and independent mechanisms and mitogen-activated protein kinases (MAPK) to direct CD8+ T cell fate.

2021-06-14 | PXD025046 | Pride

Transcriptional profile of SOX11-induced mouse epidermis

Project description:Transcriptional profile of SOX11-induced mouse epidermis

| PRJNA494643 | ENA

Transcriptional response to aneuploidy in mouse epidermis

2013-01-22 | GSE42698 | GEO

Transcriptional profile of SOX11-induced mouse epidermis

Project description:Transcriptional profiling of SOX11-expressing mouse epidermis (K14-rtTA;TRE-Sox11-FLAG) compared to control (K14-rtTA) epidermis at postnatal day 4 (P4). The littermate pairs were injected with Dox for 12 h before their epidermis was harvested. Goal was to identify the gene expression profile of postnatal epidermis changed by SOX11 induced expression.

2018-10-05 | GSE120825 | GEO

Transcriptional response to aneuploidy in mouse epidermis

Project description:Analysis of the transcriptional response to aneuploidy in mouse epidermis. In this study we measured the transcriptional response to aneuploidy by aboragting the spindle checkpoint in mouse epidermis. We found that, whereas spindle checkpoint inactivation in the epidermis is tolerated, but results in metabolic deranged cells, SAC abrogation kills bulge stem cells Mad2; K14-Cre mice were sacrificed at indicated timepoints and epidermis was separated from dermis using overnight trypsin. RNA was isolated and expression patterns were compared between K14-Cre; Mad2f/f and Cfre negative animals for all timepoints.

2013-01-22 | E-GEOD-42698 | biostudies-arrayexpress

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