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Profiling of PML-body associated regions

ABSTRACT: Profiling of PML-body associated regions

PROVIDER: PRJNA559288 | ENA |

REPOSITORIES: ENA

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Profiling of PML-body associated regions

Project description:The promyelocytic leukemia (PML) body is a phase-separated nuclear structure composed of various proteins including several chromatin regulators, and physically associates with chromatin. To address functional roles of the PML-chromatin association, we conducted genome-wide profiling of PML body-associated regions.

2019-08-14 | GSE135560 | GEO

Dissecting roles of PML bodies by genome-wide profiling of PML body-associated regions

Project description:Dissecting roles of PML bodies by genome-wide profiling of PML body-associated regions

| PRJNA559285 | ENA

Changes to the PML body proteome in U2OS cells after 2h treatment with 1uM arsenic

Project description:To monitor changes in PML body compinents during exposure to 1uM arsenic for 2h in U2OS cells lacking endogenous PML but expressing YFP-PML (V).

2024-04-11 | PXD041718 | Pride

Gene expression profiling of Pml wt and Pml KO mice liver after fasted 6h

Project description:The Pml gene is essential to the formation of PML nuclear bodies, domains which have been associated with various functions such as apoptosis/senescence, DNA repair and cell proliferation( Lallemand-Breitenbach 2010). PML-NBs formation is regulated by cellular stress including oxidative stress(Jeanne 2010, de The 2012). To investigate the role of PML in ROS response in vivo, we analyse the expression difference betweem Pml wt and Pml KO under fasted condition, which easily up-regulate ROS in BALB/cByJ background

2017-09-22 | GSE100615 | GEO

Gene expression profiling of Pml wt and Pml KO mice liver with acetaminophen (apap) overdose (300mg/kg) i.p.

Project description:The Pml gene is essential to the formation of PML nuclear bodies, domains which have been associated with various functions such as apoptosis/senescence, DNA repair and cell proliferation( Lallemand-Breitenbach 2010). PML-NBs formation is regulated by cellular stress including oxidative stress(Jeanne 2010, de The 2012). To investigate the role of PML in ROS response in vivo, we analyse the expression difference to the acetaminophen toxicity, which is initiated by ROS, in Pml wt and Pml KO mice.

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Dissecting roles of PML bodies by genome-wide profiling of PML body-associated regions

Project description:This SuperSeries is composed of the SubSeries listed below.

2019-08-14 | GSE135563 | GEO

Profiling of APEX-NLS and APEX-PMLca associated regions

Project description:Profiling of APEX-NLS and APEX-PMLca associated regions

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ATAC-seq analyses with wild-type and PML KO mESCs

Project description:Promyelocytic leukemia (PML) body is a phase-separated nuclear structure composed of various proteins including several chromatin regulators, and physically associates with chromatin, implying its crucial roles for particular genome functions. To investigate functional roles of PML bodies in chromatin organization, we conducted ATAC-seq with wild-type and PML KO mESCs.

2019-08-14 | GSE135561 | GEO

PML regulates NF-κB transcriptional activity

Project description:The transcription factor NF-κB is the master regulator of the immune response but also regulates gene expression to influences cell survival, proliferation and differentiation. Inducible site-specific phosphorylation of NF-κB is critical for its activity and appears to be important in gene specific transcriptional control. Promyelocytic Leukemia (PML) is a nuclear protein that forms sub-nuclear structures termed nuclear bodies associated with transcriptionally active genomic regions. We demonstrate that PML promotes NF-κB- induced transcriptional responses by promoting the phosphorylation of NF-κB p65 at key regulatory sites. Our findings demonstrate a critical role for PML in promoting NF-κB transcriptional activity through signal induced post-translational modifications.

2016-06-01 | GSE47828 | GEO

Effect of PML/RARA on the transcriptome of preleukemic early promyelocytes vs PML/RARA-Flt3ITD leukemic promyelocytes

Project description:Transcriptional profiling of murine cells expressing PML/RARA at the early promyelocyte stage (4 weeks old, preleukemic) and in full blown PML/RARA leukemia generated by transducing PML/RARA bone marrow with a Flt3-ITD retroviral vector

2015-07-15 | GSE59431 | GEO

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