Project description:In order to study the heterogeneity of adipose tissue in the spinal canal, we used single-cell sequencing to sequence the subcutaneous fat and adipose tissue in the spinal canal of patients with lumbar surgery at different ages.

2024-02-25 | GSE225820 | GEO

A single cell atlas of human adipose tissue

Project description:White adipose tissue (WAT), once regarded as morphologically and functionally bland, is now recognized to be dynamic, plastic, heterogenous, and involved in a wide array of biological processes including energy homeostasis, glucose and lipid handling, blood pressure control, and host defense. High fat feeding and other metabolic stressors cause dramatic changes in adipose morphology, physiology, and cellular composition, and alterations in adiposity are associated with insulin resistance, dyslipidemia, and Type 2 diabetes (T2D). Here we provide detailed cellular atlases of human and murine subcutaneous and visceral white fat at single cell resolution across a range of body weight. We identify subpopulations of adipocytes, adipose stem and progenitor cells (ASPCs), vascular, and immune cells and demonstrate commonalities and differences across species and dietary conditions. We link specific cell types to increased risk of metabolic disease, and we provide an initial blueprint for a comprehensive set of interactions between individual cell types in the adipose niche in leanness and obesity. These data comprise an extensive resource for the exploration of genes, traits, and cell types in the function of WAT across species, depots, and nutritional conditions.

2022-01-11 | GSE176171 | GEO

Human subcutaneous adipose tissue and perithyroid adipose tissue gene expression

Project description:Different human adipose tissue depots may have functional differences. Subcutaneous human adipose tissue has been extensively studied, but less is known about other depots. Perithyroid (PT) adipose tissue contains not only white adipocytes but also brown adipocytes. The aim of this study was to compare the expression of brown adipocyte containing perithyroid adipose tissue with s.c. adipose tissue.role in the development of obesity. Expression profiling of adipose tissue may give insights into mechanisms contributing to obesity and obesity-related disorders.

2013-01-22 | GSE27657 | GEO

Human subcutaneous adipose tissue and perithyroid adipose tissue gene expression

2013-01-22 | E-GEOD-27657 | biostudies-arrayexpress

Comparative analysis of gene expression in brown adipose tissue, beige adipose tissue and white adipose tissue

Project description:Comparative analysis of gene expression in brown adipose tissue, beige adipose tissue and white adipose tissue

| PRJNA551632 | ENA

Human breast adipose tissue extracellular vesicles

Project description:Proteomic analysis was performed on extracellular vesicles from human breast adipose tissue

2023-12-04 | PXD045471 | Pride

Single cell sequencing analysis of adipose tissue stroma from lean and obese female mice

Project description:We report the single cell sequencing data from subcutaneous adipose tissue CD29+ stromal cells (mesenchymal stem cells). Subcutaneous adipose tissue was collected from a mouse model of obesity and breast cancer anti-estrogen therapy. Lean and obese mice were ovariectomized, supplemented with estradiol, then maintained on estradiol, given tamoxifen, or estradiol was withdrawn for 7 weeks.

2021-09-29 | GSE180880 | GEO

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